The Spatial Pattern of Cochlear Amplification
نویسندگان
چکیده
منابع مشابه
The Spatial Pattern of Cochlear Amplification
Sensorineural hearing loss, which stems primarily from the failure of mechanosensory hair cells, changes the traveling waves that transmit acoustic signals along the cochlea. However, the connection between cochlear mechanics and the amplificatory function of hair cells remains unclear. Using an optical technique that permits the targeted inactivation of prestin, a protein of outer hair cells t...
متن کاملDetection of cochlear amplification and its activation.
The operation of the mammalian cochlea relies on a mechanical traveling wave that is actively boosted by electromechanical forces in sensory outer hair cells (OHCs). This active cochlear amplifier produces the impressive sensitivity and frequency resolution of mammalian hearing. The cochlear amplifier has inspired scientists since its discovery in the 1970s, and is still not well understood. To...
متن کاملHair-Cell Mechanotransduction and Cochlear Amplification
In the inner ear, sensory hair cells not only detect but also amplify the softest sounds, allowing us to hear over an extraordinarily wide intensity range. This amplification is frequency specific, giving rise to exquisite frequency discrimination. Hair cells detect sounds with their mechanotransduction apparatus, which is only now being dissected molecularly. Signal detection is not the only r...
متن کاملCochlear amplification, outer hair cells and prestin.
Mechanical amplification of acoustic signals is apparently a common feature of vertebrate auditory organs. In non-mammalian vertebrates amplification is produced by stereociliary processes, related to the mechanotransducer channel complex and probably to the phenomenon of fast adaptation. The extended frequency range of the mammalian cochlea has probably co-evolved with a novel hair cell type, ...
متن کاملThe role of potassium recirculation in cochlear amplification.
PURPOSE OF REVIEW Normal cochlear function depends on maintaining the correct ionic environment for the sensory hair cells. Here we review recent literature on the cellular distribution of potassium transport-related molecules in the cochlea. RECENT FINDINGS Transgenic animal models have identified novel molecules essential for normal hearing and support the idea that potassium is recycled in...
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ژورنال
عنوان ژورنال: Neuron
سال: 2012
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2012.09.031